President Hassan Rowhani says Iran is ready for “serious” negotiations on its nuclear program with the major powers.

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“We are the people of interaction and talks, with seriousness and without wasting time, if the other sides are ready,” he said on Tuesday at his first news conference since assuming office on Saturday.

“Iran’s peaceful nuclear program is a national issue… we will not give up the rights of the Iranian people,” he said.

“We will preserve our rights based on the international regulations,” he added, in reference to Iran’s insistence that it has the right to peaceful use of nuclear power as a signatory to the Non-Proliferation Treaty.

“As the president of the Islamic republic, I am announcing that there is political will to solve this issue and also take into consideration the concerns of the other sides.”

Rowhani hit out a call by 76 US senators for tougher sanctions from Washington even as he took office with a call for constructive engagement.

He said Friday’s letter from the US lawmakers to President Barack Obama showed a lack of understanding of Iranian politics.

“Recent declarations from the the White House show that some US officials do not have a correct and realistic assessment of the situation here and the message that the Iranian people gave in the election,” Rowhani said.

“They are still sending contradictory messages,” he said, adding: “We care about the US response in deeds, not in words.”

On Sunday, the White House said Iran would find the United States a “willing partner” if Rowhani is prepared to engage substantively and seriously on its nuclear program.

In a message congratulating Rowhani on his inauguration, the White House said it “presents an opportunity for Iran to act quickly to resolve the international community’s deep concerns over Iran’s nuclear program”.